Epac activation inhibits IL-6-induced cardiac myocyte dysfunction

Pro-inflammatory cytokines are released in septic shock and impair cardiac function via the Jak-STAT pathway. It is well known that sympathetic and thus catecholamine signaling is activated thereafter to compensate for cardiac dysfunction. The mechanism of such compensation by catecholamine signalin...

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Detalhes bibliográficos
Publicado no:J Physiol Sci
Main Authors: Jin, Huiling, Fujita, Takayuki, Jin, Meihua, Kurotani, Reiko, Hidaka, Yuko, Cai, Wenqian, Suita, Kenji, Prajapati, Rajesh, Liang, Chen, Ohnuki, Yoshiki, Mototani, Yasumasa, Umemura, Masanari, Yokoyama, Utako, Sato, Motohiko, Okumura, Satoshi, Ishikawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2016
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353818/
https://ncbi.nlm.nih.gov/pubmed/27995459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12576-016-0509-5
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