Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β(2)-adrenoceptor stimulation

The predominant isoform of β-adrenoceptor (β-AR) in skeletal muscle is β(2)-AR and that in the cardiac muscle is β(1)-AR. We have reported that Epac1 (exchange protein directly activated by cAMP 1), a new protein kinase A-independent cAMP sensor, does not affect cardiac hypertrophy in response to pr...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Ohnuki, Yoshiki, Umeki, Daisuke, Mototani, Yasumasa, Jin, Huiling, Cai, Wenqian, Shiozawa, Kouichi, Suita, Kenji, Saeki, Yasutake, Fujita, Takayuki, Ishikawa, Yoshihiro, Okumura, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2014
Assuntos:
Muscle
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270506/
https://ncbi.nlm.nih.gov/pubmed/25344550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.282996
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