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Knockout of Human Arylamine N-Acetyltransferase 1 (NAT1) in MDA-MB-231 Breast Cancer Cells Leads to Increased Reserve Capacity, Maximum Mitochondrial Capacity, and Glycolytic Reserve Capacity

INTRODUCTION: Human arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. NAT1 can also hydrolyze acetyl-coenzyme A (acetyl-CoA) in the absence of an arylamine substrate. Expression of NAT1 varies between individuals and is elevated in sever...

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Detalhes bibliográficos
Publicado no:Mol Carcinog
Main Authors: Carlisle, Samantha M., Trainor, Patrick J., Doll, Mark A., Stepp, Marcus W., Klinge, Carolyn M., Hein, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353662/
https://ncbi.nlm.nih.gov/pubmed/29964355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22869
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