Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer’s disease pathogenesis

Alzheimer’s disease is pathologically defined by accumulation of extracellular amyloid-β (Aβ). Approximately 25 mutations in β-amyloid precursor protein (APP) are pathogenic and cause autosomal dominant Alzheimer’s disease. To date, the mechanism underlying the effect of APP mutation on Aβ generatio...

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Bibliographic Details
Published in:Neural Regen Res
Main Authors: Li, Nuo-Min, Liu, Ke-Fu, Qiu, Yun-Jie, Zhang, Huan-Huan, Nakanishi, Hiroshi, Qing, Hong
Format: Artigo
Language:Inglês
Published: Medknow Publications & Media Pvt Ltd 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352587/
https://ncbi.nlm.nih.gov/pubmed/30632506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.247469
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