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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease

Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early onset of disease. The clinical course and neuropathology of FAD and sporadic Alzheimer's disease are highly similar,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Weggen, Sascha, Beher, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334542/
https://ncbi.nlm.nih.gov/pubmed/22494386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt107
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