Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

BACKGROUND: Transient depletion of CD4(+) T cells results in tumor suppression and survival benefit in murine models; however, the tumor progression and recurrence still occur over more long-term monitoring of mice. Thus, we explored an additional strategy to enhance endogenous immune responses by a...

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Pubblicato in:J Immunother Cancer
Autori principali: Chen, Chang-Yu, Ueha, Satoshi, Ishiwata, Yoshiro, Yokochi, Shoji, Yang, De, Oppenheim, Joost J., Ogiwara, Haru, Shichino, Shigeyuki, Deshimaru, Shungo, Shand, Francis H. W., Shibayama, Shiro, Matsushima, Kouji
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352494/
https://ncbi.nlm.nih.gov/pubmed/30696484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0503-6
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