TCR Repertoire Analysis Reveals Mobilization of Novel CD8(+) T Cell Clones Into the Cancer-Immunity Cycle Following Anti-CD4 Antibody Administration

Depletion of CD4(+) cells using an anti-CD4 monoclonal antibody (anti-CD4 mAb) induces the expansion of tumor-reactive CD8(+) T cells and strong antitumor effects in several murine tumor models. However, it is not known whether the anti-CD4 mAb treatment activates a particular or a broad spectrum of...

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書目詳細資料
發表在:Front Immunol
Main Authors: Aoki, Hiroyasu, Ueha, Satoshi, Shichino, Shigeyuki, Ogiwara, Haru, Hashimoto, Shin-ichi, Kakimi, Kazuhiro, Ito, Satoru, Matsushima, Kouji
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353793/
https://ncbi.nlm.nih.gov/pubmed/30733724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03185
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