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Phosphorylation at the D53 but Not the T65 Residue of CovR Determines the Repression of rgg and speB Transcription in emm1- and emm49-Type Group A Streptococci
CovR/CovS is a two-component regulatory system in group A Streptococcus and primarily acts as a transcriptional repressor. The D53 residue of CovR (CovR(D53)) is phosphorylated by the sensor kinase CovS, and the phosphorylated CovR(D53) protein binds to the intergenic region of rgg-speB to inhibit s...
Gardado en:
| Publicado en: | J Bacteriol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6351742/ https://ncbi.nlm.nih.gov/pubmed/30478086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00681-18 |
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