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Phosphorylation at the D53 but Not the T65 Residue of CovR Determines the Repression of rgg and speB Transcription in emm1- and emm49-Type Group A Streptococci

CovR/CovS is a two-component regulatory system in group A Streptococcus and primarily acts as a transcriptional repressor. The D53 residue of CovR (CovR(D53)) is phosphorylated by the sensor kinase CovS, and the phosphorylated CovR(D53) protein binds to the intergenic region of rgg-speB to inhibit s...

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Detalhes bibliográficos
Publicado no:J Bacteriol
Main Authors: Chiang-Ni, Chuan, Kao, Chih-Yuan, Hsu, Chih-Yun, Chiu, Cheng-Hsun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351742/
https://ncbi.nlm.nih.gov/pubmed/30478086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00681-18
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