Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo

Autophagy-lysosome pathway (ALP) disruption is considered pathogenic in multiple neurodegenerative diseases; however, current methods are inadequate to investigate macroautophagy/autophagy flux in brain in vivo and its therapeutic modulation. Here, we describe a novel autophagy reporter mouse (TRGL6...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Lee, Ju-Hyun, Rao, Mala V., Yang, Dun-Sheng, Stavrides, Philip, Im, Eunju, Pensalfini, Anna, Huo, Chunfeng, Sarkar, Pallabi, Yoshimori, Tamotsu, Nixon, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351128/
https://ncbi.nlm.nih.gov/pubmed/30269645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1528812
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