The Preferable Binding Pose of Canonical Butyrylcholinesterase Substrates Is Unproductive for Echothiophate

In this paper, we, for the first time, describe the interaction between the butyrylcholinesterase enzyme and echothiophate, a popular model compound and an analogue of the chemical warfare agents VX and VR, at the atomistic level. Competition between the two echothiophate conformations in the active...

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Vydáno v:Acta Naturae
Hlavní autoři: Zlobin, A. S., Zalevsky, A. O., Mokrushina, Yu. A., Kartseva, O. V., Golovin, A. V., Smirnov, I. V.
Médium: Artigo
Jazyk:Inglês
Vydáno: A.I. Gordeyev 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351040/
https://ncbi.nlm.nih.gov/pubmed/30713771
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