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MECHANISTIC ANALYSIS OF CO-CRYSTAL DISSOLUTION, SURFACE pH, AND DISSOLUTION ADVANTAGE AS A GUIDE FOR RATIONAL SELECTION
The dissolution behavior of a dibasic drug ketoconazole (KTZ) under the influence of pH has been evaluated and compared to its three 1:1 co-crystals with diacidic coformers, fumaric acid (FUM), succinic acid (SUC) and adipic acid (ADP). Mass transport models were developed by applying Fick’s Law of...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6350789/ https://ncbi.nlm.nih.gov/pubmed/30278187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.09.028 |
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