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Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration

Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the subretinal space. This limits the extent of the retina...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Methods Clin Dev
Auteurs principaux: Song, Hongman, Bush, Ronald A., Zeng, Yong, Qian, Haohua, Wu, Zhijian, Sieving, Paul A.
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350231/
https://ncbi.nlm.nih.gov/pubmed/30719486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.12.006
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