Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing

ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated sa...

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Publicado en:Sci Rep
Autores principales: Vautrin, Audrey, Manchon, Laurent, Garcel, Aude, Campos, Noëlie, Lapasset, Laure, Laaref, Abdelhamid Mahdi, Bruno, Roman, Gislard, Marie, Dubois, Emeric, Scherrer, Didier, Ehrlich, J Hartmut, Tazi, Jamal
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349857/
https://ncbi.nlm.nih.gov/pubmed/30692590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37813-y
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