Amplified Host Defense by Toll-Like Receptor-Mediated Downregulation of the Glucocorticoid-Induced Leucine Zipper (GILZ) in Macrophages

Activation of toll-like receptors (TLRs) plays a pivotal role in the host defense against bacteria and results in the activation of NF-κB-mediated transcription of proinflammatory mediators. Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory mediator, which inhibits NF-κB activity...

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Udgivet i:Front Immunol
Main Authors: Hoppstädter, Jessica, Diesel, Britta, Linnenberger, Rebecca, Hachenthal, Nina, Flamini, Sara, Minet, Marie, Leidinger, Petra, Backes, Christina, Grässer, Friedrich, Meese, Eckart, Bruscoli, Stefano, Riccardi, Carlo, Huwer, Hanno, Kiemer, Alexandra K.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349698/
https://ncbi.nlm.nih.gov/pubmed/30723476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03111
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