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Tyrosine hydroxylase inhibition in substantia nigra decreases movement frequency

Reduced movement frequency or physical activity (bradykinesia) occurs with high prevalence in the elderly. However, loss of striatal tyrosine hydroxylase (TH) in aging humans, non-human primates, or rodents does not reach the ~80% loss threshold associated with bradykinesia onset in Parkinson’s dise...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Neurobiol
Main Authors: Salvatore, Michael F, McInnis, Tamara R., Cantu, Mark A., Apple, Deana M., Pruett, Brandon S.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349536/
https://ncbi.nlm.nih.gov/pubmed/30056575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1256-9
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