FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles

The fibroblast growth factor FGF21 was labeled with molecularly defined gold nanoparticles (AuNPs), applied to human adipocytes, and imaged by cryo-electron tomography (cryo-ET). Most AuNPs were in pairs about 80 Å apart, on the outer cell surface. Pairs of AuNPs were also abundant inside the cells...

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Bibliographic Details
Published in:eLife
Main Authors: Azubel, Maia, Carter, Stephen D, Weiszmann, Jennifer, Zhang, Jun, Jensen, Grant J, Li, Yang, Kornberg, Roger D
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349402/
https://ncbi.nlm.nih.gov/pubmed/30688648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.43146
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