Aminothiazoles inhibit osteoclastogenesis and PGE (2) production in LPS‐stimulated co‐cultures of periodontal ligament and RAW 264.7 cells, and RANKL‐mediated osteoclastogenesis and bone resorption in PBMCs

Inflammatory mediator prostaglandin E(2) (PGE (2)) contributes to bone resorption in several inflammatory conditions including periodontitis. The terminal enzyme, microsomal prostaglandin E synthase‐1 (mPGES‐1) regulating PGE (2) synthesis is a promising therapeutic target to reduce inflammatory bon...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Kats, Anna, Gerasimcik, Natalija, Näreoja, Tuomas, Nederberg, Jonas, Grenlöv, Simon, Lagnöhed, Ekaterina, Desai, Suchita, Andersson, Göran, Yucel‐Lindberg, Tülay
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349150/
https://ncbi.nlm.nih.gov/pubmed/30506812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14015
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