Aminothiazoles inhibit osteoclastogenesis and PGE (2) production in LPS‐stimulated co‐cultures of periodontal ligament and RAW 264.7 cells, and RANKL‐mediated osteoclastogenesis and bone resorption in PBMCs

Inflammatory mediator prostaglandin E(2) (PGE (2)) contributes to bone resorption in several inflammatory conditions including periodontitis. The terminal enzyme, microsomal prostaglandin E synthase‐1 (mPGES‐1) regulating PGE (2) synthesis is a promising therapeutic target to reduce inflammatory bon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Mol Med
Prif Awduron: Kats, Anna, Gerasimcik, Natalija, Näreoja, Tuomas, Nederberg, Jonas, Grenlöv, Simon, Lagnöhed, Ekaterina, Desai, Suchita, Andersson, Göran, Yucel‐Lindberg, Tülay
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349150/
https://ncbi.nlm.nih.gov/pubmed/30506812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14015
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