A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan

To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library. Ame55 had lower bioactivity than cetuximab in vitro but similar antitumor efficacy as cetuximab in vivo. Mo...

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Vydáno v:J Immunol Res
Hlavní autoři: Qiu, Weiyi, Zhang, Chang, Wang, Shuang, Yu, Xiaoyan, Wang, Qiong, Zeng, Dadi, Du, Peng, Ma, Jinling, Zheng, Yiqiong, Pang, Bo, Yu, Yunzhou, Long, Feng, Pang, Xiaobin, Sun, Zhiwei
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348820/
https://ncbi.nlm.nih.gov/pubmed/30733972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3017360
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