Epigenetic therapy combinations in acute myeloid leukemia: what are the options?

Epigenetics refers to the regulation of gene expression mainly by changes in DNA methylation and modifications of histone proteins without altering the actual DNA sequence. While epigenetic modifications are essential for normal cell differentiation, several driver mutations in leukemic pathogenesis...

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Bibliographic Details
Published in:Ther Adv Hematol
Main Authors: Bewersdorf, Jan Philipp, Shallis, Rory, Stahl, Maximilian, Zeidan, Amer M.
Format: Artigo
Language:Inglês
Published: SAGE Publications 2019
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348528/
https://ncbi.nlm.nih.gov/pubmed/30719265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040620718816698
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