In Silico Engineering of Synthetic Binding Proteins from Random Amino Acid Sequences

Synthetic proteins with high affinity and selectivity for a protein target can be used as research tools, biomarkers, and pharmacological agents, but few methods exist to design such proteins de novo. To this end, the In-Silico Protein Synthesizer (InSiPS) was developed to design synthetic binding p...

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Publicat a:iScience
Autors principals: Burnside, Daniel, Schoenrock, Andrew, Moteshareie, Houman, Hooshyar, Mohsen, Basra, Prabh, Hajikarimlou, Maryam, Dick, Kevin, Barnes, Brad, Kazmirchuk, Tom, Jessulat, Matthew, Pitre, Sylvain, Samanfar, Bahram, Babu, Mohan, Green, James R., Wong, Alex, Dehne, Frank, Biggar, Kyle K., Golshani, Ashkan
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348295/
https://ncbi.nlm.nih.gov/pubmed/30660105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.11.038
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