Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury

OBJECTIVE: The average age at the time of spinal cord injury (SCI) has increased to 43 years old. Middle-aged mice (14 months old, MO) exhibit impaired recovery after SCI with age-dependent increases in reactive oxygen species (ROS) production through NADPH oxidase (NOX) along with pro-inflammatory...

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Bibliographic Details
Published in:Brain Behav Immun
Main Authors: Zhang, Bei, Bailey, William M., McVicar, Anna Leigh, Stewart, Andrew N., Veldhorst, Amy K., Gensel, John C.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348135/
https://ncbi.nlm.nih.gov/pubmed/30453022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2018.11.013
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