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Removal of Microglial-Specific MyD88 Signaling Alters Dentate Gyrus Doublecortin and Enhances Opioid Addiction-like Behaviors

Drugs of abuse promote a potent immune response in central nervous system (CNS) via the activation of microglia and astrocytes. However, the molecular mechanisms underlying microglial activation during addiction are not well known. We developed and functionally characterized a novel transgenic mouse...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Rivera, Phillip D., Hanamsagar, Richa, Kan, Matthew J., Tran, Phuong K, Stewart, David, Jo, Young Chan, Gunn, Michael, Bilbo, Staci D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348129/
https://ncbi.nlm.nih.gov/pubmed/30447281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2018.11.010
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