The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma

ABSTRACT: No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. IC(50) value...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Med (Berl)
Prif Awduron: Laszlo, Viktoria, Valko, Zsuzsanna, Ozsvar, Judit, Kovacs, Ildiko, Garay, Tamas, Hoda, Mir Alireza, Klikovits, Thomas, Stockhammer, Paul, Aigner, Clemens, Gröger, Marion, Klepetko, Walter, Berger, Walter, Grusch, Michael, Tovari, Jozsef, Waizenegger, Irene C., Dome, Balazs, Hegedus, Balazs
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2018
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348072/
https://ncbi.nlm.nih.gov/pubmed/30539198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-018-1725-7
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