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The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma
ABSTRACT: No tyrosine kinase inhibitors are approved for malignant pleural mesothelioma (MPM). Preclinical studies identified focal adhesion kinase (FAK) as a target in MPM. Accordingly, we assessed the novel, highly selective FAK inhibitor (BI 853520) in 2D and 3D cultures and in vivo. IC(50) value...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Mol Med (Berl) |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Springer Berlin Heidelberg
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6348072/ https://ncbi.nlm.nih.gov/pubmed/30539198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-018-1725-7 |
| Tagiau: |
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