Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

Epigenetic modifications confer stable transcriptional patterns in the brain and both normal and abnormal brain function involve specialized brain regions. We examined DNA methylation by whole genome bisulfite sequencing in neuronal and non-neuronal populations from four brain regions (anterior cing...

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Veröffentlicht in:Nat Neurosci
Hauptverfasser: Rizzardi, Lindsay F., Hickey, Peter F., DiBlasi, Varenka Rodriguez, Tryggvadóttir, Rakel, Callahan, Colin M., Idrizi, Adrian, Hansen, Kasper D., Feinberg, Andrew P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348048/
https://ncbi.nlm.nih.gov/pubmed/30643296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0297-8
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