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Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

Epigenetic modifications confer stable transcriptional patterns in the brain and both normal and abnormal brain function involve specialized brain regions. We examined DNA methylation by whole genome bisulfite sequencing in neuronal and non-neuronal populations from four brain regions (anterior cing...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Rizzardi, Lindsay F., Hickey, Peter F., DiBlasi, Varenka Rodriguez, Tryggvadóttir, Rakel, Callahan, Colin M., Idrizi, Adrian, Hansen, Kasper D., Feinberg, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348048/
https://ncbi.nlm.nih.gov/pubmed/30643296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0297-8
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