FGL2 promotes tumor progression in the CNS by suppressing CD103(+) dendritic cell differentiation

Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout in tumor cells did not affect tumor-cell proli...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yan, Jun, Zhao, Qingnan, Gabrusiewicz, Konrad, Kong, Ling-Yuan, Xia, Xueqing, Wang, Jian, Ott, Martina, Xu, Jingda, Davis, R. Eric, Huo, Longfei, Rao, Ganesh, Sun, Shao-Cong, Watowich, Stephanie S., Heimberger, Amy B., Li, Shulin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347641/
https://ncbi.nlm.nih.gov/pubmed/30683885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08271-x
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