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Chronic Stress and Intestinal Permeability: Lubiprostone Regulates Glucocorticoid Receptor-mediated Changes in Colon Epithelial Tight Junction Proteins, Barrier Function and Visceral Pain in The Rodent and Human
BACKGROUND: Chronic psychological stress is associated with increased intestinal epithelial permeability and visceral hyperalgesia. Lubiprostone, an agonist for chloride channel-2, promotes secretion and accelerates restoration of injury-induced epithelial barrier dysfunction. The mechanisms underly...
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| Pubblicato in: | Neurogastroenterol Motil |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6347514/ https://ncbi.nlm.nih.gov/pubmed/30284340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nmo.13477 |
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