Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Late endosome-resident interferon-induced transmembrane protein 3 (IFITM3) inhibits fusion of diverse viruses, including Influenza A virus (IAV), by a poorly understood mechanism. Despite the broad antiviral activity of IFITM3, viruses like Lassa virus (LASV), are fully resistant to its inhibitory e...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Suddala, Krishna C., Lee, Christine C., Meraner, Paul, Marin, Mariana, Markosyan, Ruben M., Desai, Tanay M., Cohen, Fredric S., Brass, Abraham L., Melikyan, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347298/
https://ncbi.nlm.nih.gov/pubmed/30640957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007532
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