Cyclodextrins as multifunctional excipients: Influence of inclusion into β-cyclodextrin on physicochemical and biological properties of tebipenem pivoxil

A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed. The formation of the tebipenem pivoxil-β-cyclodextrin (TP-β-CD) complex resulted in changes concerning physicochemical properties of TP, which is significant for planning the development of...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Paczkowska, Magdalena, Szymanowska-Powałowska, Daria, Mizera, Mikołaj, Siąkowska, Dominika, Błaszczak, Wioletta, Piotrowska-Kempisty, Hanna, Cielecka-Piontek, Judyta
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347292/
https://ncbi.nlm.nih.gov/pubmed/30682086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210694
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