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An algorithm for computing profile likelihood based pointwise confidence intervals for nonlinear dose-response models

This study was inspired by the need to estimate pointwise confidence intervals (CIs) for a nonlinear dose-response model from a dose-finding clinical trial. Profile likelihood based CI for a nonlinear dose response model is often recommended. However, it is still not commonly used in dose-finding st...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ren, Xiaowei, Xia, Jielai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347253/
https://ncbi.nlm.nih.gov/pubmed/30682081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210953
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