Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea

BACKGROUND: Erythromycin A (Er-A) produced by the actinomycete Saccharopolyspora erythraea is an important antibiotic extensively used in human medicine. Dissecting of transcriptional regulators and their target genes associated with erythromycin biosynthesis is crucial to obtain erythromycin overpr...

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Publicat a:J Biol Eng
Autors principals: Wu, Hang, Chu, Zuling, Zhang, Wanxiang, Zhang, Chi, Ni, Jingshu, Fang, Heshi, Chen, Yuhong, Wang, Yansheng, Zhang, Lixin, Zhang, Buchang
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346578/
https://ncbi.nlm.nih.gov/pubmed/30697347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13036-018-0135-2
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