Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea

BACKGROUND: Erythromycin A (Er-A) produced by the actinomycete Saccharopolyspora erythraea is an important antibiotic extensively used in human medicine. Dissecting of transcriptional regulators and their target genes associated with erythromycin biosynthesis is crucial to obtain erythromycin overpr...

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Foilsithe in:J Biol Eng
Main Authors: Wu, Hang, Chu, Zuling, Zhang, Wanxiang, Zhang, Chi, Ni, Jingshu, Fang, Heshi, Chen, Yuhong, Wang, Yansheng, Zhang, Lixin, Zhang, Buchang
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2019
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346578/
https://ncbi.nlm.nih.gov/pubmed/30697347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13036-018-0135-2
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