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Tissue acidosis does not mediate the hypoxia selectivity of [(64)Cu][Cu(ATSM)] in the isolated perfused rat heart
Copper-64-Diacetyl-bis(N(4)-methylthiosemicarbazone) [(64)Cu][Cu(ATSM)] is a hypoxia-targeting PET tracer with applications in oncology and cardiology. Upon entering a hypoxic cell, [(64)Cu][Cu(II)(ATSM)] is reduced to a putative [(64)Cu][Cu(I)(ATSM)](−) species which dissociates to deposit radiocop...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6346098/ https://ncbi.nlm.nih.gov/pubmed/30679497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36145-1 |
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