Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer

DNA replication timing is known to facilitate the establishment of the epigenome, however, the intimate connection between replication timing and changes to the genome and epigenome in cancer remain largely uncharacterised. Here, we perform Repli-Seq and integrated epigenome analyses and demonstrate...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Du, Qian, Bert, Saul A., Armstrong, Nicola J., Caldon, C. Elizabeth, Song, Jenny Z., Nair, Shalima S., Gould, Cathryn M., Luu, Phuc-Loi, Peters, Timothy, Khoury, Amanda, Qu, Wenjia, Zotenko, Elena, Stirzaker, Clare, Clark, Susan J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345877/
https://ncbi.nlm.nih.gov/pubmed/30679435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08302-1
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