Application of the Transcriptional Disease Signature (TDSs) to Screen Melanoma-Effective Compounds in a Small Fish Model

Cell culture and protein target-based compound screening strategies, though broadly utilized in selecting candidate compounds, often fail to eliminate candidate compounds with non-target effects and/or safety concerns until late in the drug developmental process. Phenotype screening using intact res...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lu, Yuan, Boswell, William, Boswell, Mikki, Klotz, Barbara, Kneitz, Susanne, Regneri, Janine, Savage, Markita, Mendoza, Cristina, Postlethwait, John, Warren, Wesley C., Schartl, Manfred, Walter, Ronald B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345854/
https://ncbi.nlm.nih.gov/pubmed/30679619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36656-x
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