Application of the Transcriptional Disease Signature (TDSs) to Screen Melanoma-Effective Compounds in a Small Fish Model

Cell culture and protein target-based compound screening strategies, though broadly utilized in selecting candidate compounds, often fail to eliminate candidate compounds with non-target effects and/or safety concerns until late in the drug developmental process. Phenotype screening using intact res...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Lu, Yuan, Boswell, William, Boswell, Mikki, Klotz, Barbara, Kneitz, Susanne, Regneri, Janine, Savage, Markita, Mendoza, Cristina, Postlethwait, John, Warren, Wesley C., Schartl, Manfred, Walter, Ronald B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345854/
https://ncbi.nlm.nih.gov/pubmed/30679619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36656-x
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg