Fibrogenic Gene Expression in Hepatic Stellate Cells Induced by HCV and HIV Replication in a Three Cell Co-Culture Model System

Retrospective studies indicate that co-infection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) accelerates hepatic fibrosis progression. We have developed a co-culture system (MLH) comprising primary macrophages, hepatic stellate cells (HSC, LX-2), and hepatocytes (Huh-7), permis...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Akil, Abdellah, Endsley, Mark, Shanmugam, Saravanabalaji, Saldarriaga, Omar, Somasunderam, Anoma, Spratt, Heidi, Stevenson, Heather L., Utay, Netanya S., Ferguson, Monique, Yi, MinKyung
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345841/
https://ncbi.nlm.nih.gov/pubmed/30679661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37071-y
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