Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

Microtubule-targeting agents (MTAs) are widely used chemotherapy drugs capable of disrupting microtubule-dependent cellular functions, such as division and migration. We show that two clinically approved MTAs, paclitaxel and vinblastine, each suppress stiffness-sensitive migration and polarization c...

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Udgivet i:Cell Rep
Main Authors: Prahl, Louis S., Bangasser, Patrick F., Stopfer, Lauren E., Hemmat, Mahya, White, Forest M., Rosenfeld, Steven S., Odde, David J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345402/
https://ncbi.nlm.nih.gov/pubmed/30485822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.101
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