Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration

Type 1 interferons (IFN) are an antiviral cytokine family, important in juvenile onset systemic lupus erythematosus (jSLE) which is more common in females, around puberty. We report that plasmacytoid dendritic cells (pDC) from healthy females produced more type 1 IFN after toll like receptor (TLR) 7...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Webb, Kate, Peckham, Hannah, Radziszewska, Anna, Menon, Madhvi, Oliveri, Paola, Simpson, Fraser, Deakin, Claire T., Lee, Sophie, Ciurtin, Coziana, Butler, Gary, Wedderburn, Lucy R., Ioannou, Yiannis
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345344/
https://ncbi.nlm.nih.gov/pubmed/30705679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03167
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