CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α

Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and skin rash. B cells are strongly implicated in the pathogenesis of the disease, but the underlying mechanisms are unknown. Therefore, the main objective of our study was to i...

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Bibliografiska uppgifter
Huvudupphovsmän: Christopher J. M. Piper, Meredyth G. Ll. Wilkinson, Claire T. Deakin, Georg W. Otto, Stefanie Dowle, Chantal L. Duurland, Stuart Adams, Emiliano Marasco, Elizabeth C. Rosser, Anna Radziszewska, Rita Carsetti, Yiannis Ioannou, Philip L. Beales, Daniel Kelberman, David A. Isenberg, Claudia Mauri, Kiran Nistala, Lucy R. Wedderburn
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018-06-01
Serie:Frontiers in Immunology
Ämnen:
immature transitional B cells
B cells
juvenile dermatomyositis
toll-like receptor 7
interferon alpha
interleukin-10
Länkar:https://www.frontiersin.org/article/10.3389/fimmu.2018.01372/full
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