CD19(+)CD24(hi)CD38(hi) B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α

Juvenile dermatomyositis (JDM) is a rare form of childhood autoimmune myositis that presents with proximal muscle weakness and skin rash. B cells are strongly implicated in the pathogenesis of the disease, but the underlying mechanisms are unknown. Therefore, the main objective of our study was to i...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Piper, Christopher J. M., Wilkinson, Meredyth G. Ll., Deakin, Claire T., Otto, Georg W., Dowle, Stefanie, Duurland, Chantal L., Adams, Stuart, Marasco, Emiliano, Rosser, Elizabeth C., Radziszewska, Anna, Carsetti, Rita, Ioannou, Yiannis, Beales, Philip L., Kelberman, Daniel, Isenberg, David A., Mauri, Claudia, Nistala, Kiran, Wedderburn, Lucy R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6024011/
https://ncbi.nlm.nih.gov/pubmed/29988398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01372
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