Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage‐specific neurons. However, current strategies mainly rely on genome‐integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced...

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Vydáno v:Stem Cells Transl Med
Hlavní autoři: Xue, Yingchao, Zhan, Xiping, Sun, Shisheng, Karuppagounder, Senthilkumar S., Xia, Shuli, Dawson, Valina L., Dawson, Ted M., Laterra, John, Zhang, Jianmin, Ying, Mingyao
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2018
Témata:
Pluripotent Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344911/
https://ncbi.nlm.nih.gov/pubmed/30387318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.18-0036
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