Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage‐specific neurons. However, current strategies mainly rely on genome‐integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Xue, Yingchao, Zhan, Xiping, Sun, Shisheng, Karuppagounder, Senthilkumar S., Xia, Shuli, Dawson, Valina L., Dawson, Ted M., Laterra, John, Zhang, Jianmin, Ying, Mingyao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2018
Assuntos:
Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344911/
https://ncbi.nlm.nih.gov/pubmed/30387318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.18-0036
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