Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage‐specific neurons. However, current strategies mainly rely on genome‐integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced...

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Dades bibliogràfiques
Publicat a:Stem Cells Transl Med
Autors principals: Xue, Yingchao, Zhan, Xiping, Sun, Shisheng, Karuppagounder, Senthilkumar S., Xia, Shuli, Dawson, Valina L., Dawson, Ted M., Laterra, John, Zhang, Jianmin, Ying, Mingyao
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2018
Matèries:
Pluripotent Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344911/
https://ncbi.nlm.nih.gov/pubmed/30387318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.18-0036
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