Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation

Non-resolved persistent macrophage-mediated synovial inflammation is considered as one of the main drivers of both the establishment and progression of obesity-associated osteoarthritis (OA). Herein, we used clodronate-loaded liposomes (CL) to locally deplete macrophages in the synovial joints to ex...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sun, Antonia Rujia, Wu, Xiaoxin, Liu, Bohao, Chen, Yang, Armitage, Charles W., Kollipara, Avinash, Crawford, Ross, Beagley, Kenneth W., Mao, Xinzhan, Xiao, Yin, Prasadam, Indira
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344566/
https://ncbi.nlm.nih.gov/pubmed/30674985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36909-9
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