Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system

To address the unmet needs for human polyclonal antibodies both as therapeutics and diagnostic reagents, building upon our previously established transchromosomic (Tc) cattle platform, we report herein the development of a Tc goat system expressing human polyclonal antibodies in their sera. In the T...

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Udgivet i:Sci Rep
Main Authors: Wu, Hua, Fan, Zhiqiang, Brandsrud, Michelle, Meng, Qinggang, Bobbitt, Molly, Regouski, Misha, Stott, Rusty, Sweat, Alexis, Crabtree, Jackelyn, Hogan, Robert J., Tripp, Ralph A., Wang, Zhongde, Polejaeva, Irina A., Sullivan, Eddie J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344498/
https://ncbi.nlm.nih.gov/pubmed/30675003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36961-5
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