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Methylation Products of 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators

Two 6β-N-heterocyclic naltrexamine derivatives, NAP and NMP, have been identified as peripherally selective mu opioid receptor (MOR) antagonists. To further enhance the peripheral selectivity of both compounds, the 17-amino group and the nitrogen atom of the pyridine ring in both NAP and NMP were me...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Zheng, Yi, Obeng, Samuel, Wang, Huiqun, Stevens, David L., Komla, Essie, Selley, Dana E., Dewey, William L., Akbarali, Hamid I., Zhang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344324/
https://ncbi.nlm.nih.gov/pubmed/30001114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00234
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