Redox Activation of Nox1 Involves an Intermolecular Disulfide Bond between Protein Disulfide Isomerase and p47(phox) in Vascular Smooth Muscle Cells

OBJECTIVE: Protein disulfide isomerase A1 (PDI) was reported to support Nox1 NADPH oxidase (Nox1) activation mediated by growth factors in vascular smooth muscle cells. Our aim was to investigate the molecular mechanism by which PDI activates Nox1 and the functional implications of PDI in Nox1-activ...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Gimenez, Marcela, Veríssimo-Filho, Sidney, Wittig, Ilka, Schickling, Brandon M., Hahner, Fabian, Schürmann, Christoph, Netto, Luis E.S., Rosa, José César, Brandes, Ralf P., Sartoretto, Simone, Lucca Camargo, Lívia De, Abdulkader, Fernando, Miller, Francis J., Lopes, Lucia Rossetti
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344286/
https://ncbi.nlm.nih.gov/pubmed/30580571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311038
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