Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome of 6 to 7 day-old P. cynomolgi liver stages, high...

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Publicado en:eLife
Autores principales: Bertschi, Nicole L, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Knehr, Judith, Gupta, Devendra K, Hofman, Sam O, van der Werff, Nicole, Nieuwenhuis, Ivonne, Klooster, Els, Faber, Bart W, Flannery, Erika L, Mikolajczak, Sebastian A, Chuenchob, Vorada, Shrestha, Binesh, Beibel, Martin, Bouwmeester, Tewis, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Diagana, Thierry T, Kocken, Clemens HM, Roma, Guglielmo
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344078/
https://ncbi.nlm.nih.gov/pubmed/30589413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41081
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