Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome of 6 to 7 day-old P. cynomolgi liver stages, high...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bertschi, Nicole L, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Knehr, Judith, Gupta, Devendra K, Hofman, Sam O, van der Werff, Nicole, Nieuwenhuis, Ivonne, Klooster, Els, Faber, Bart W, Flannery, Erika L, Mikolajczak, Sebastian A, Chuenchob, Vorada, Shrestha, Binesh, Beibel, Martin, Bouwmeester, Tewis, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Diagana, Thierry T, Kocken, Clemens HM, Roma, Guglielmo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344078/
https://ncbi.nlm.nih.gov/pubmed/30589413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41081
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