Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer’s disease

Heterozygous TREM2 mutations are an Alzheimer’s disease (AD) risk factor. Non-mutated TREM2 dysregulation occurs in AD brain. Whether TREM2 is altered in prodromal AD remains unknown. Western blotting was used to determine levels of TREM2 (~ 25 kDa) and Iba1 in the frontal cortex and TREM2 in the hi...

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Gepubliceerd in:Neurobiol Aging
Hoofdauteurs: Perez, Sylvia E., Nadeem, Muhammad, He, Bin, Miguel, Jennifer C., Malek-Ahmadi, Michael H., Chen, Kewei, Mufson, Elliott J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344038/
https://ncbi.nlm.nih.gov/pubmed/28365005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.02.012
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