Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells. Dissecting the underlying mechanisms that block cytokine production is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Salerno, Fiamma, Guislain, Aurelie, Freen-Van Heeren, Julian J., Nicolet, Benoit P., Young, Howard A., Wolkers, Monika C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343783/
https://ncbi.nlm.nih.gov/pubmed/30713785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1532762
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